A bacterial infection most prevalent in herbavores such as cattle, sheep,
horses and goats. Humans
are relatively resistant to infection
with estimates ranging from 20,000 to 100,000 cases per year, worldwide.
It can infect the skin, lungs, intestine and the brain. The skin infection
begins with a small red macule, progressing within one week to an ulcer
with a blackened necrotic crust surrounded by a zone of brawny edema. Inhalation
anthrax presents as a respiratory infection, which develops suddenly, subsides
after a few days then returns with more severe symptoms of cough, shortness
of breath and rapid deterioration. It is characterized by bleeding within
the chest wall. Untreated inhalation anthrax carries 100% mortality.
Early treatment with IV antibiotics ( Cipro, PCN G, Streptomycin ) reduce
mortality to the 60% range. Intestinal anthrax presents with fever, nausea,
vomiting, abdominal pain, ascites(fluid within the abdomen), and bloody
diarrhea. In the Oropharyngeal type, there is sore throat, fever, difficulty
swallowing, and painful swollen lymph nodes. Anthrax Menningitis is rare.
Treatment is with intravenous Pennicillin G, Doxycycline or Ciprofloxacin
either alone or in combination with streptomycin. Current vaccines have
been shown to be quite effective against inhalation anthrax in Rhesus monkeys,
and have considerable protection against cutaneous anthrax in humans. Existing
supplies are used to vaccinate only military personnel. Mortality from
treated skin anthrax is very low; from treated intestinal anthrax, 30%.
Prevention in suspected exposure can be achieved by a six week course of
Doxycycline or Ciprofloxacin.